Rabbit Secondary Antibodies
ABclonal Technology 488 Rabbit anti-Human IL-2
This gene is a member of the interleukin 2 (IL2) cytokine subfamily which includes IL4 IL7 IL9 IL15 IL21 erythropoietin and thrombopoietin The protein encoded by this gene is a secreted cytokine produced by activated CD4 and CD8 T lymphocytes that is important for the proliferation of T and B lymphocytes The receptor of this cytokine (IL2R) is a heterotrimeric protein complex whose gamma chain is also shared by IL4 and IL7 The expression of this gene in mature thymocytes is monoallelic which represents an unusual regulatory mode for controlling the precise expression of a single gene The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease which suggests an essential role of this gene in the immune response to antigenic stimuli
ABclonal Technology 488 Rabbit anti-Human CD153
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family This cytokine is a ligand for TNFRSF8 CD30 which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch This cytokine was shown to enhance cell proliferation of some lymphoma cell lines while to induce cell death and reduce cell proliferation of other lymphoma cell lines The pleiotropic biologic activities of this cytokine on different CD30 lymphoma cell lines may play a pathophysiologic role in Hodgkin s and some non-Hodgkin s lymphomas Two transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 700 Rabbit anti-Human CD38
The protein encoded by this gene is a non-lineage-restricted type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5 -diphosphate-ribose an intracellular calcium ion mobilizing messenger The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein This protein has an N-terminal cytoplasmic tail a single membrane-spanning domain and a C-terminal extracellular region with four N-glycosylation sites Crystal structure analysis demonstrates that the functional molecule is a dimer with the central portion containing the catalytic site It is used as a prognostic marker for patients with chronic lymphocytic leukemia Alternative splicing results in multiple transcript variants
ABclonal Technology APC Rabbit anti-Human CD79a
The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component surface immunoglobulin (Ig) Surface Ig non-covalently associates with two other proteins Ig-alpha and Ig-beta which are necessary for expression and function of the B-cell antigen receptor This gene encodes the Ig-alpha protein of the B-cell antigen component Alternatively spliced transcript variants encoding different isoforms have been described
ABclonal Technology 700 Rabbit anti-Human CD1c
This gene encodes a member of the CD1 family of transmembrane glycoproteins which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells The human genome contains five CD1 family genes organized in a cluster on chromosome 1 The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail Alternatively spliced transcript variants of this gene have been observed but their full-length nature is not known
ABclonal Technology 647 Rabbit anti-Human CD59
This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis and it is involved in lymphocyte signal transduction This protein is a potent inhibitor of the complement membrane attack complex whereby it binds complement C8 and or C9 during the assembly of this complex thereby inhibiting the incorporation of multiple copies of C9 into the complex which is necessary for osmolytic pore formation This protein also plays a role in signal transduction pathways in the activation of T cells Mutations in this gene cause CD59 deficiency a disease resulting in hemolytic anemia and thrombosis and which causes cerebral infarction Multiple alternatively spliced transcript variants which encode the same protein have been identified for this gene
ABclonal Technology 594 Rabbit anti-Human CD35
Complement receptor type 1 (CR1 CD35) is a type I transmembrane glycoprotein that is expressed on the surface of B cells neutrophils monocytes and renal podocytes As a component of the host s innate immune system CR1 CD35 expressed on neutrophils and monocytes binds to ligands coated with complement opsonins C3b and C4b thereby promoting phagocytosis and pro-inflammatory cytokine production CR1 CD35 also participates in negative regulation of the complement cascade through its ability to promote dissociation of C3 and C5 convertases and by serving as one of multiple cofactors for factor-I-mediated cleavage and inactivation of C3b and C4b
ABclonal Technology 488 Rabbit anti-Human CD142
This gene encodes coagulation factor III a cell surface glycoprotein essential for initiating blood coagulation It acts as a high-affinity receptor for factor VII forming a complex that triggers protease cascades via limited proteolysis Unlike other coagulation cofactors factor III is fully functional when expressed on cell surfaces such as on monocytes It has extracellular transmembrane and cytoplasmic domains Platelets and monocytes express this factor during procoagulatory and proinflammatory responses Factor III is implicated in HIV-related coagulopathy and is associated with COVID-19 severity and mortality Notably congenital deficiency of this protein has not been observed Multiple transcript variants exist due to alternative splicing
ABclonal Technology 647 Rabbit anti-Human CD1d
This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells The human genome contains five CD1 family genes organized in a cluster on chromosome 1 The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail Two transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 594 Rabbit anti-Human CD86
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily This protein is expressed by antigen-presenting cells and it is the ligand for two proteins at the cell surface of T cells CD28 antigen and cytotoxic T-lymphocyte-associated protein 4 Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response Alternative splicing results in several transcript variants encoding different isoforms
Abcam Rabbit Anti-Human IgG H&L (Biotin).
Rabbit Anti-Human IgG H&L (Biotin).
The product is subject to the following: Abcam Restricted Use Statement
ABclonal Technology 488 Rabbit anti-Human CD27
The protein encoded by this gene is a member of the TNF-receptor superfamily This receptor is required for generation and long-term maintenance of T cell immunity It binds to ligand CD70 and plays a key role in regulating B-cell activation and immunoglobulin synthesis This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8 JNK Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor CD27-binding protein (SIVA) a proapoptotic protein can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor
ABclonal Technology 647 Rabbit anti-Human CD28
The protein encoded by this gene is essential for T-cell proliferation and survival cytokine production and T-helper type-2 development Several alternatively spliced transcript variants encoding different isoforms have been found for this gene
Immunoreagents Inc RABBIT A-LLAMA IGG FITC
Secondary Antibody; Rabbit anti-llama IgG (H&L) - Affinity Pure, FITC Conjugate, Host: Rabbit, Format: Liq, Label: FITC, Applications: WB, ELISA, IHC/ICC, IF, IP, FC, FACS
Immunoreagents Inc RABBIT A-LLAMA IGG DYLIGHT550
Secondary Antibody; Rabbit anti-llama IgG (H&L) - Affinity Pure, DyLight 550 Conjugate, Host: Rabbit, Format: Lyo, Label: DyL550, Applications: WB, ELISA, IHC/ICC, IF, IP, FC, FACS